Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X7SD
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| Former ID |
DNC010462
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| Drug Name |
2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine
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| Synonyms |
CHEMBL20666; N,N-dimethyl-2-(2-phenylphenoxy)ethanamine; 2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine; AC1LHJ83; ZINC4913607; BDBM50307494; MCULE-6428005896
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H19NO
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| Canonical SMILES |
CN(C)CCOC1=CC=CC=C1C2=CC=CC=C2
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| InChI |
1S/C16H19NO/c1-17(2)12-13-18-16-11-7-6-10-15(16)14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3
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| InChIKey |
HEGXUUYKFGNKJB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 7 receptor (HTR7) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Ras signaling pathway | |||
| Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. | |||
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