Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X8ID
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| Former ID |
DIB000487
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| Drug Name |
SEL-24
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| Synonyms |
Multikinase inhibitor (cancer), Selvita; SEL-24-1; SEL-24-11; SEL-24-20; Pim-1 kinase inhibitors (cancer), Selvita
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 1/2 | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [2] | ||
| Company |
Selvita Life Sciences Solutions
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fms-like tyrosine kinase 3 (FLT-3) | Target Info | Inhibitor | [1] |
| Serine/threonine-protein kinase pim-1 (PIM1) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Jak-STAT signaling pathway | |||
| MicroRNAs in cancer | ||||
| Acute myeloid leukemia | ||||
| Cytokine-cytokine receptor interaction | ||||
| Hematopoietic cell lineage | ||||
| Pathways in cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Central carbon metabolism in cancer | ||||
| NetPath Pathway | IL9 Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| TCR Signaling Pathway | ||||
| Pathway Interaction Database | GMCSF-mediated signaling events | |||
| Validated targets of C-MYC transcriptional activation | ||||
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | ||||
| IL5-mediated signaling events | ||||
| IL3-mediated signaling events | ||||
| C-MYB transcription factor network | ||||
| WikiPathways | Ectoderm Differentiation | |||
| Hematopoietic Stem Cell Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158). | |||
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