Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0XU7N
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| Former ID |
DNC003413
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| Drug Name |
10-CF3C(OH)2-DDACTHF
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| Synonyms |
Hydrolyzed Form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H30F3N5O8
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| Canonical SMILES |
C1=CC(=CC=C1C(CCCC2C(NC(NC2=O)N)N)C(C(F)(F)F)(O)O)C(=O)NC(CCC(=O)O)C(=O)O
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| InChI |
1S/C22H30F3N5O8/c23-22(24,25)21(37,38)13(3-1-2-12-16(26)29-20(27)30-18(12)34)10-4-6-11(7-5-10)17(33)28-14(19(35)36)8-9-15(31)32/h4-7,12-14,16,20,29,37-38H,1-3,8-9,26-27H2,(H,28,33)(H,30,34)(H,31,32)(H,35,36)/t12-,13+,14-,16+,20-/m1/s1
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| InChIKey |
KOLDLUFBEMUZIM-WUAYEBGVSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycinamide ribonucleotide formyltransferase (GART) | Target Info | Inhibitor | [1] |
| BioCyc | Purine nucleotides de novo biosynthesis | |||
| 5-aminoimidazole ribonucleotide biosynthesis | ||||
| Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate | ||||
| KEGG Pathway | Purine metabolism | |||
| One carbon pool by folate | ||||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | De novo purine biosynthesis | |||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | |||
| WikiPathways | One Carbon Metabolism | |||
| Metabolism of nucleotides | ||||
| Folate Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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