Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y2RR
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| Former ID |
DNC007271
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| Drug Name |
1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one
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| Synonyms |
CHEMBL225618; 3,3',4,4'-tetrahydroxychalcone; 1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one; SCHEMBL109015; BDBM50157562; 3,3'',4,4''-tetrahydroxychalcone; ZINC13541162
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H12O5
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| Canonical SMILES |
C1=CC(=C(C=C1C=CC(=O)C2=CC(=C(C=C2)O)O)O)O
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| InChI |
1S/C15H12O5/c16-11(10-3-6-13(18)15(20)8-10)4-1-9-2-5-12(17)14(19)7-9/h1-8,17-20H/b4-1+
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| InChIKey |
DOWSJIIZLUFMFM-DAFODLJHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
| KEGG Pathway | HTLV-I infection | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| Regulation of Telomerase | ||||
| IL2 signaling events mediated by PI3K | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
| WikiPathways | TGF beta Signaling Pathway | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Telomere Maintenance | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Catecholic flavonoids acting as telomerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6466-75. | |||
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