Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y4JJ
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| Former ID |
DAP000525
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| Drug Name |
Bepridil
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| Synonyms |
Bepadin; Vascor; CERM 1978; Bepadin (TN); Bepridil (INN); Vascor (TN); N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline; Beta-((2-Methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine; N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-yl-propyl]aniline hydrochloride; N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline; N-{3-[(2-methylpropyl)oxy]-2-pyrrolidin-1-ylpropyl}-N-(phenylmethyl)aniline
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| Drug Type |
Small molecular drug
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| Indication | Chronic/stable angina [ICD-11: BA40.1; ICD-9: 413] | Approved | [1], [2] | |
| Therapeutic Class |
Antiarrhythmic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C24H34N2O
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| Canonical SMILES |
CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3
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| InChI |
1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3
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| InChIKey |
UIEATEWHFDRYRU-UHFFFAOYSA-N
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| CAS Number |
CAS 64706-54-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9065, 5424488, 7978773, 8151577, 11120268, 11120756, 11121244, 11121366, 11121846, 11335285, 11360524, 11362435, 11364639, 11364997, 11367201, 11367559, 11369763, 11370141, 11370142, 11371654, 11373160, 11374413, 11375721, 11377925, 11461496, 11466396, 11467516, 11484478, 11486152, 11488717, 11490563, 11492612, 11495559, 14755108, 24262992, 26755663, 26755664, 29221519, 46506353, 47217021, 47217022, 47217023, 47440509, 47736734, 47811007, 47811008, 48035374, 48035375, 48035376, 48110710
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| ChEBI ID |
CHEBI:3061
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| ADReCS Drug ID | BADD_D00254 | |||
| SuperDrug ATC ID |
C08EA02
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| SuperDrug CAS ID |
cas=064706543
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides thetaiotaomicron
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Bepridil hydrochloride (adjusted p-values: 7.47E-03). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Bepridil hydrochloride (adjusted p-values: 8.12E-03). | |||
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Studied Microbe: Parabacteroides distasonis
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Bepridil hydrochloride (adjusted p-values: 2.37E-03). | |||
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Studied Microbe: Parabacteroides merdae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Bepridil hydrochloride (adjusted p-values: 7.30E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Bepridil hydrochloride (adjusted p-values: 1.03E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Bepridil hydrochloride (adjusted p-values: 8.81E-05). | |||
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Studied Microbe: Clostridium perfringens
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Bepridil hydrochloride (adjusted p-values: 4.79E-03). | |||
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Studied Microbe: Dorea formicigenerans
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Bepridil hydrochloride (adjusted p-values: 9.13E-03). | |||
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Studied Microbe: Enterocloster bolteae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Bepridil hydrochloride (adjusted p-values: 1.33E-03). | |||
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Studied Microbe: Eubacterium eligens
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Bepridil hydrochloride (adjusted p-values: 2.13E-04). | |||
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Studied Microbe: Eubacterium rectale
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Bepridil hydrochloride (adjusted p-values: 1.66E-03). | |||
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Studied Microbe: Roseburia intestinalis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Bepridil hydrochloride (adjusted p-values: 2.13E-03). | |||
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Studied Microbe: Ruminococcus gnavus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Bepridil hydrochloride (adjusted p-values: 5.48E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Streptococcus salivarius
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Bepridil hydrochloride (adjusted p-values: 8.50E-03). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Modulator | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2337). | |||
| REF 2 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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