Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y5QO
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| Former ID |
DIB012490
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| Drug Name |
GK-128
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| Indication | Vomiting [ICD-11: MD90; ICD-10: R11; ICD-9: 787] | Terminated | [1] | |
| Company |
Taisho Pharmaceutical Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H15ClN2OS
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| Canonical SMILES |
CC1=NC=CN1CC2=CSC3=C(C2=O)C4=CC=CC=C4C=C3.Cl
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| InChI |
1S/C18H14N2OS.ClH/c1-12-19-8-9-20(12)10-14-11-22-16-7-6-13-4-2-3-5-15(13)17(16)18(14)21;/h2-9,11H,10H2,1H3;1H
|
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| InChIKey |
DBXKJORICFHAQA-UHFFFAOYSA-N
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| CAS Number |
CAS 162413-52-7
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002051) | |||
| REF 2 | Effect of a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, GK-128, on 5-HT3 receptors mediating contractions and relaxations in guinea-pig distal colon. Gen Pharmacol. 1997 Sep;29(3):353-9. | |||
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