Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y5QR
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| Former ID |
DNC000112
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| Drug Name |
8R-Lisuride
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| Synonyms |
BKRGVLQUQGGVSM-RDTXWAMCSA-N; S-(-)-Lisuride; 8R-lisuride; NCGC00163158-01; Biomol-NT_000024; Lopac0_000781; BPBio1_001092; CHEMBL1528238; CHEBI:93550; BDBM22867; CCG-204866; L-122; EU-0100781; SR-01000075971; SR-01000075971-1; BRD-K88871508-001-01-9; 1,1-diethyl-3-(9,10-didehydro-6-methyl-8beta-ergolinyl)urea; N'-(9,10-Didehydro-6-methylergoline-8beta-yl)-N,N-diethylurea; 1,1-diethyl-3-[(8beta)-6-methyl-9,10-didehydroergolin-8-yl]urea; S(-)-N'-[(8a)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethyl-urea
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C20H26N4O
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| Canonical SMILES |
CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
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| InChI |
1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18-/m1/s1
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| InChIKey |
BKRGVLQUQGGVSM-RDTXWAMCSA-N
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| CAS Number |
CAS 140387-89-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:93550
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Agonist | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 8R-lisuride is a potent stereospecific histamine H1-receptor partial agonist. Mol Pharmacol. 2004 Mar;65(3):538-49. | |||
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