Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y6OX
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| Former ID |
DIB020701
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| Drug Name |
PGJ2
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| Synonyms |
9-deoxy-delta-9-prostaglandin D2; prostaglandin J2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C20H30O4
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| Canonical SMILES |
CCCCCC(C=CC1C(C=CC1=O)CC=CCCCC(=O)O)O
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| InChI |
1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1
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| InChIKey |
UQOQENZZLBSFKO-POPPZSFYSA-N
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| CAS Number |
CAS 60203-57-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8241, 622948, 4265963, 8616423, 14717670, 14875409, 16292254, 24898809, 26754825, 26754826, 39289873, 47290905, 47364933, 48184759, 50064970, 50110794, 53789299, 56314008, 57357909, 75792191, 85788964, 92309914, 99300828, 99302346, 104046448, 113854164, 126524632, 135066857, 135651542, 137030368, 139340644, 164756549, 179205578, 184568147, 231498309, 241337640, 242205529, 250132936, 252455638, 252457384
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| ChEBI ID |
CHEBI:27485
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin D2 receptor (PTGDR) | Target Info | Agonist | [2] |
| Prostaglandin D2 receptor 2 (PTGDR2) | Target Info | Agonist | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Pathwhiz Pathway | Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 | |||
| Pathway Interaction Database | Thromboxane A2 receptor signaling | |||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (s) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1885). | |||
| REF 2 | Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. | |||
| REF 3 | Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. | |||
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