Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y6UB
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| Former ID |
DNC000053
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| Drug Name |
2-PMPA
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| Synonyms |
2-(Phosphonomethyl)pentanedioic acid; 2-(phosphonomethyl)pentanedioic acid; 173039-10-6; PMPA (NAALADase inhibitor); CHEMBL47009; 2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID; PMPA(NAALADaseinhibitor); 2-PMPA(NAALADaseinhibitor); SCHEMBL383173; BDBM17659; KS-00001CPM; CTK0E4395; DTXSID90436036; MolPort-023-276-085; ISEYJGQFXSTPMQ-UHFFFAOYSA-N; HMS3267D10; 2-Phosphonomethyl-pentanedioic acid; EX-A1248; pentanedioic acid analogue, (RS)-1; ANW-62579; AKOS016004257; API0001123; 2-PMPA, > MP-2042; CS-6202; Pentanedioic acid, 2-(phosphonomethyl)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C6H11O7P
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| Canonical SMILES |
C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
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| InChI |
1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
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| InChIKey |
ISEYJGQFXSTPMQ-UHFFFAOYSA-N
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| CAS Number |
CAS 173039-10-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15121544, 22533549, 39969184, 46517820, 50002643, 50112859, 57374253, 77250760, 103230319, 125640593, 128212870, 134224448, 134339598, 134340806, 137010259, 142391146, 160830077, 162022820, 162448650, 163394392, 163843169, 172873791, 180677325, 184538750, 186020734, 189614600, 204418430, 226713916, 241182379, 242069708, 249841889, 250182203, 250212573, 252045761, 252212931, 252328680, 252433515, 252560384
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate carboxypeptidase II (GCPII) | Target Info | Inhibitor | [1], [2] |
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | |||
| Metabolic pathways | ||||
| Vitamin digestion and absorption | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| Reactome | Amino acid synthesis and interconversion (transamination) | |||
| WikiPathways | One Carbon Metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design and synthesis of a siderophore conjugate as a potent PSMA inhibitor and potential diagnostic agent for prostate cancer. Bioorg Med Chem. 2008 Feb 15;16(4):1648-57. | |||
| REF 2 | Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat Med. 1999 Dec;5(12):1396-402. | |||
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