Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y7DP
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| Former ID |
DNC001491
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| Drug Name |
Uridine
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| Synonyms |
uridine; 58-96-8; Uridin; Uracil riboside; beta-Uridine; d-uridine; CHEBI:16704; b-Uridine; UNII-WHI7HQ7H85; Urd; AI3-52690; EINECS 200-407-5; WHI7HQ7H85; MLS000069625; Uracil-1-beta-d-ribofuranoside; C9H12N2O6; DRTQHJPVMGBUCF-XVFCMESISA-N; SMR000058222; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione
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| Drug Type |
Small molecular drug
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| Indication | Depression [ICD-11: 6A70-6A7Z; ICD-9: 311] | Approved | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H12N2O6
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| Canonical SMILES |
C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
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| InChI |
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
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| InChIKey |
DRTQHJPVMGBUCF-XVFCMESISA-N
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| CAS Number |
CAS 58-96-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3275, 3593, 584045, 825827, 3134852, 3718411, 7891023, 8139953, 8144667, 8153756, 12109174, 14710325, 14847540, 15221017, 24900434, 24900638, 24900640, 26702452, 26715956, 26754144, 29225043, 46167442, 46391419, 46504323, 48095962, 49833656, 50059626, 56459453, 57323128, 77021584, 81044517, 81092927, 85164984, 85230753, 87577750, 88835504, 92298506, 99226784, 99438033, 103313732, 103852268, 104310914, 117358157, 117613647, 118048883, 123059964, 124525105, 124799625, 124882993, 126523145
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| ChEBI ID |
CHEBI:16704
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [3] |
| BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Bladder cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Bladder Cancer | |||
| Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4566). | |||
| REF 2 | ClinicalTrials.gov (NCT00210080) A Study to Diagnose Lung Cancer by Sputum Cytology (01-312). U.S. National Institutes of Health. | |||
| REF 3 | Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10. | |||
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