Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y8EU
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| Former ID |
DNC000961
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| Drug Name |
MRS-1220
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| Synonyms |
MRS 1220; 183721-15-5; MRS-1220; CHEMBL88147; N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-2-phenylacetamide; MRS1220; N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide; MRS 1200; NSC 695674; Tocris-1217; MRS 1220, solid; AC1Q3QZX; 9-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline; GTPL448; SCHEMBL927261; AC1L96H4; CTK8F0085; CHEBI:92667; MolPort-003-958-674; ZINC602092; HMS3267D09; NSC695674; BDBM50053929; AKOS024456471; NSC-695674
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H14ClN5O2
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| Canonical SMILES |
C1=CC=C(C=C1)CC(=O)NC2=NC3=C(C=C(C=C3)Cl)C4=NC(=NN42)C5=CC=CO5
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| InChI |
1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28)
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| InChIKey |
TWWFAXQOKNBUCR-UHFFFAOYSA-N
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| CAS Number |
CAS 183721-15-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
524902, 4962537, 7978522, 10280040, 11113966, 11438593, 14928432, 24896720, 26752111, 56459401, 57402361, 79893430, 85209185, 85788645, 91721454, 103295938, 103838465, 103950597, 104619372, 117467439, 129325621, 131306782, 135337698, 135650648, 135698354, 137054394, 142146734, 162022819, 162226562, 163124997, 184594867, 204366636, 208265240, 223468630, 227189785, 241182239, 241375304, 252215848
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| ChEBI ID |
CHEBI:92667
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A3 receptor (ADORA3) | Target Info | Antagonist | [2] |
| Reactome | Adenosine P1 receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Nucleotide GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 448). | |||
| REF 2 | A(3) adenosine receptor activation attenuates neutrophil function and neutrophil-mediated reperfusion injury. Am J Physiol. 1999 Nov;277(5 Pt 2):H1895-905. | |||
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