Drug Information
Drug General Information | Top | |||
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Drug ID |
D0YH0N
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Former ID |
DIB005117
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Drug Name |
Metadoxine
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Synonyms |
MG01CI; Metadoxine (oral sustained release, ADHD); Metadoxine (oral extended release, ADHD), Alcobra; Metadoxine (oral sustained release, ADHD), Alcobra
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Drug Type |
Small molecular drug
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Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90; ICD-9: 203] | Approved | [1], [2] | |
Company |
Alcobra
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Structure |
Download2D MOL |
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Formula |
C13H18N2O6
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Canonical SMILES |
CC1=NC=C(C(=C1O)CO)CO.C1CC(=O)NC1C(=O)O
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InChI |
1S/C8H11NO3.C5H7NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5;7-4-2-1-3(6-4)5(8)9/h2,10-12H,3-4H2,1H3;3H,1-2H2,(H,6,7)(H,8,9)/t;3-/m.0/s1
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InChIKey |
RYKKQQUKJJGFMN-HVDRVSQOSA-N
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CAS Number |
CAS 74536-44-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | GABA transporter GAT-1 (SLC6A1) | Target Info | Modulator | [3] |
KEGG Pathway | GABAergic synapse | |||
Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
WikiPathways | Monoamine Transport | |||
NRF2 pathway |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02051842) Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis. U.S. National Institutes of Health. | |||
REF 2 | Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease. Hum Psychopharmacol. 2011 Dec;26(8):554-9. | |||
REF 3 | Company report (Alcobra pharma) |
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