Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YN5P
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| Former ID |
DNC000108
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| Drug Name |
8-aminoquinolines
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| Synonyms |
Hexamethonium; hexamethonium; Hexonium; Benzohexamethonium; Hexamethonum; Bistrium; Hexanium; 60-26-4; UNII-3C9PSP36Z2; Esametonio [Italian]; CHEMBL100622; CHEBI:5700; 3C9PSP36Z2; N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium; NCGC00163239-01; Hexane-1,6-bis(trimethylammonium); 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-; DSSTox_RID_80651; DSSTox_CID_25053; DSSTox_GSID_45053; BRN 1760389; Esametonio; CHEMBL332524; CAS-60-26-4; Hexamethonium [INN]; Ammonium, hexamethylenebis(trimethyl-; trimethyl-[6-(trimethylazaniumyl)hexyl]azanium
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H30N2+2
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| Canonical SMILES |
C[N+](C)(C)CCCCCC[N+](C)(C)C
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| InChI |
1S/C12H30N2/c1-13(2,3)11-9-7-8-10-12-14(4,5)6/h7-12H2,1-6H3/q+2
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| InChIKey |
VZJFGSRCJCXDSG-UHFFFAOYSA-N
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| CAS Number |
CAS 60-26-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9713, 4562732, 7760437, 7979533, 8152273, 11111255, 11111256, 11335838, 11361077, 11364553, 11367115, 11369677, 11371887, 11374600, 11377839, 11462049, 11466066, 11467186, 11485160, 11485792, 11489368, 11490779, 11492895, 11495473, 12075313, 15017947, 26756596, 29222730, 47216780, 47291134, 47365192, 47440259, 47515320, 47736485, 47885417, 48110452, 48259232, 49698986, 50111094, 50111095, 57321891, 79539038, 81065625, 90340749, 90340750, 103945790, 104037961, 104303989, 124749858, 124880277
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| ChEBI ID |
CHEBI:5700
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acetylcholine receptor (nAChR) | Target Info | Antagonist | [3] |
| Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3963). | |||
| REF 2 | The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp Parasitol. 1994 Aug;79(1):50-6. | |||
| REF 3 | Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ. 1994 Oct;5(10):1033-40. | |||
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