Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z0HH
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| Former ID |
DNC000701
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| Drug Name |
Gossypol
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| Synonyms |
gossypol; 303-45-7; (-)-Gossypol; 90141-22-3; (+)-Gossypol; Pogosin; Tash 1; racemic-Gossypol; (R)-(-)-Gossypol; (R)-Gossypol; (+-)-Gossypol; (+/-)-Gossypol; CCRIS 2689; NSC56817; NSC 56817; NSC 624336; BRN 1917878; CHEMBL51483; AI3-22957; 20300-26-9; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde; 2,2'-bi[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]; 2,2'-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene); NSC624336; Gossypol acetate
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| Drug Type |
Small molecular drug
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| Indication | Prostate cancer [ICD-11: 2C82.0; ICD-10: C61; ICD-9: 185] | Phase 2 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C30H30O8
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| Canonical SMILES |
CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O
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| InChI |
1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
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| InChIKey |
QBKSWRVVCFFDOT-UHFFFAOYSA-N
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| CAS Number |
CAS 20300-26-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9869, 106063, 491707, 596303, 597024, 617882, 7351426, 7979433, 8137017, 8139932, 8152224, 10321940, 11112318, 11114252, 11335348, 11341873, 11360587, 11362056, 11363253, 11364415, 11365815, 11366977, 11368377, 11369539, 11372123, 11372790, 11374589, 11375440, 11376539, 11377701, 11405981, 11408781, 11446919, 11461559, 11466705, 11467825, 11485159, 11485423, 11486430, 11487458, 11489288, 11489440, 11490917, 11491331, 11492661, 11493745, 11494173, 11495335, 12013187, 14811578
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| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4204). | |||
| REF 2 | ClinicalTrials.gov (NCT00848016) Gossypol Acetic Acid in Treating Patients With Recurrent, Metastatic, or Primary Adrenocortical Cancer That Cannot Be Removed By Surgery. U.S. National Institutes of Health. | |||
| REF 3 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | |||
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