Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z5GR
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| Former ID |
DNC010336
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| Drug Name |
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine
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| Synonyms |
CHEMBL599593; 1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H16ClN3O
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| Canonical SMILES |
C1CN(CCN1)C2=C(N=CC=C2)OC3=CC=CC=C3Cl
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| InChI |
1S/C15H16ClN3O/c16-12-4-1-2-6-14(12)20-15-13(5-3-7-18-15)19-10-8-17-9-11-19/h1-7,17H,8-11H2
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| InChIKey |
LVSZWRFDLAUNPF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Inhibitor | [1] |
| Norepinephrine transporter (NET) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| Serotonin receptors | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Serotonin HTR1 Group and FOS Pathway | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. | |||
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