Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z7GS
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| Former ID |
DNC011271
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| Drug Name |
6-Fluoromelatonin
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| Synonyms |
6-Fluoromelatonin; 62106-00-7; CHEMBL333886; N-(2-(6-Fluoro-5-methoxy-1H-indol-3-yl)ethyl)acetamide; N-[2-(6-fluoro-5-methoxy-1H-indol-3-yl)ethyl]acetamide; ACETAMIDE, N-(2-(6-FLUORO-5-METHOXY-1H-INDOL-3-YL)ETHYL)-; AC1L2ASC; SCHEMBL1772618; SCHEMBL1772619; DTXSID10211165; BTTITVUHHXXLFM-UHFFFAOYSA-N; ZINC2032560; BDBM50330858; LS-9627; N-[2-(5-methoxy-6-fluoroindol-3-yl)ethyl]acetamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H15FN2O2
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| Canonical SMILES |
CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)F
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| InChI |
1S/C13H15FN2O2/c1-8(17)15-4-3-9-7-16-12-6-11(14)13(18-2)5-10(9)12/h5-7,16H,3-4H2,1-2H3,(H,15,17)
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| InChIKey |
BTTITVUHHXXLFM-UHFFFAOYSA-N
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| CAS Number |
CAS 62106-00-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2B receptor (HTR2B) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86. | |||
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