Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z7QK
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Drug Name |
UCART123
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Drug Type |
CAR T Cell Therapy
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Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 1 | [1] | |
Blastic plasmacytoid dendritic cell neoplasm [ICD-11: 2A60.5; ICD-10: C86.4] | Phase 1 | [1] | ||
Company |
Cellectis S.A.
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Target and Pathway | Top | |||
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Target(s) | Interleukin 3 receptor alpha (IL3RA) | Target Info | CAR-T-Cell-Therapy | [2], [3] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
PI3K-Akt signaling pathway | ||||
Apoptosis | ||||
Jak-STAT signaling pathway | ||||
Hematopoietic cell lineage | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
IL3 Signaling Pathway | ||||
Pathway Interaction Database | IL3-mediated signaling events | |||
Reactome | GPVI-mediated activation cascade | |||
G beta:gamma signalling through PI3Kgamma | ||||
Interleukin-3, 5 and GM-CSF signaling | ||||
RAF/MAP kinase cascade | ||||
Interleukin receptor SHC signaling | ||||
WikiPathways | IL-3 Signaling Pathway | |||
Interleukin-2 signaling | ||||
Interleukin-3, 5 and GM-CSF signaling |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 2 | ClinicalTrials.gov (NCT03190278) Study Evaluating Safety and Efficacy of UCART123 in Patients With Acute Myeloid Leukemia | |||
REF 3 | ClinicalTrials.gov (NCT03203369) Study to Evaluate the Safety and Clinical Activity of UCART123 in Patients With BPDCN |
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