Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z8HG
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Former ID |
DAP000354
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Drug Name |
Vecuronium
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Synonyms |
Norcuron (TN); (2A,3A,5A,16A,17A)-3,17-diacetoxy-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane; (2beta,3alpha,5alpha,16beta,17beta)-3,17-diacetoxy-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane; [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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Drug Type |
Small molecular drug
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Indication | Spasm [ICD-11: MB47.3; ICD-10: R25.2; ICD-9: 338,780] | Approved | [1], [2] | |
Therapeutic Class |
Analgesics
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Company |
Bedford Laboratories
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Structure |
Download2D MOL |
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Formula |
C34H57N2O4+
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Canonical SMILES |
CC(=O)OC1CC2CCC3C(C2(CC1N4CCCCC4)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C
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InChI |
1S/C34H57N2O4/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36/h25-32H,6-22H2,1-5H3/q+1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
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InChIKey |
BGSZAXLLHYERSY-XQIGCQGXSA-N
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CAS Number |
CAS 86029-43-8
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:9939
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ADReCS Drug ID | BADD_D02341 | |||
SuperDrug ATC ID |
M03AC03
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SuperDrug CAS ID |
cas=050700726
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Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia obeum
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[3] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Blautia obeum was decreased by Vecuronium bromide (adjusted p-values: 1.40E-04). | |||
Studied Microbe: Dorea formicigenerans
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[3] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Dorea formicigenerans was decreased by Vecuronium bromide (adjusted p-values: 7.45E-04). | |||
Studied Microbe: Eubacterium rectale
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[3] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium rectale was decreased by Vecuronium bromide (adjusted p-values: 3.02E-04). | |||
Studied Microbe: Ruminococcus gnavus
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[3] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus gnavus was decreased by Vecuronium bromide (adjusted p-values: 5.44E-04). |
Target and Pathway | Top | |||
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Target(s) | Neuronal acetylcholine receptor alpha-2 (CHRNA2) | Target Info | Antagonist | [4], [5] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||
Highly calcium permeable nicotinic acetylcholine receptors | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4002). | |||
REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
REF 4 | Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. | |||
REF 5 | Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. |
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