Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z9HW
|
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| Former ID |
DCL000474
|
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| Drug Name |
AZD6280
|
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| Drug Type |
Small molecular drug
|
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z] | Discontinued in Phase 1 | [1] | |
| Schizophrenia [ICD-11: 6A20] | Discontinued in Phase 1 | [1] | ||
| Company |
AstraZeneca
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C20H22N4O3
|
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| Canonical SMILES |
CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC(=C3)OC)OC
|
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| InChI |
1S/C20H22N4O3/c1-4-10-22-20(25)19-17(21)14-7-5-6-13(18(14)23-24-19)15-11-12(26-2)8-9-16(15)27-3/h5-9,11H,4,10H2,1-3H3,(H2,21,23)(H,22,25)
|
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| InChIKey |
NVWCZRPXYVDQEE-UHFFFAOYSA-N
|
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| CAS Number |
CAS 942436-93-3
|
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-3 (GABRA3) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027607) | |||
| REF 2 | AZD6280, a novel partial -aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers.J Clin Psychopharmacol.2015 Feb;35(1):22-33. | |||
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