Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0ZU9Z
|
|||
Former ID |
DIB020277
|
|||
Drug Name |
LY320135
|
|||
Synonyms |
LY 320135; LY-320135
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
|
|||
Formula |
C24H17NO4
|
|||
Canonical SMILES |
COC1=CC=C(C=C1)C2=C(C3=C(O2)C=C(C=C3)OC)C(=O)C4=CC=C(C=C4)C#N
|
|||
InChI |
1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3
|
|||
InChIKey |
RYNSGDFWBJWWSZ-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 176977-56-3
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
7979825, 11056385, 14878087, 26753297, 39340961, 57309758, 57359407, 75783703, 85209155, 85788701, 103567317, 114155682, 124891595, 129200182, 135309795, 135337496, 135650548, 135698232, 136353063, 137066043, 141566793, 162023390, 162247377, 163123871, 172841720, 176227145, 184538767, 198974090, 202558953, 204369924, 215781298, 223468606, 223532833, 225373242, 229726154, 251960633, 252141330, 252156472, 252266394, 252373266, 252451046
|
|||
ChEBI ID |
CHEBI:93387
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [2] |
KEGG Pathway | Rap1 signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | ||||
Panther Pathway | Endogenous cannabinoid signaling | |||
Pathway Interaction Database | N-cadherin signaling events | |||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Small Ligand GPCRs | ||||
BDNF signaling pathway | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 742). | |||
REF 2 | LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan;284(1):291-7. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.