Drug Information
Drug General Information | Top | |||
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Drug ID |
D0ZX7I
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Former ID |
DIB014632
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Drug Name |
SR-57227
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Synonyms |
SR-57227A
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Drug Type |
Small molecular drug
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Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Discontinued in Phase 2 | [1], [2] | |
Company |
Sanofi
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Structure |
Download2D MOL |
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Formula |
C10H14ClN3
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Canonical SMILES |
C1CN(CCC1N)C2=NC(=CC=C2)Cl
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InChI |
1S/C10H14ClN3/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14/h1-3,8H,4-7,12H2
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InChIKey |
WPVVMKYQOMJPIN-UHFFFAOYSA-N
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CAS Number |
CAS 77145-51-8
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PubChem Compound ID | ||||
PubChem Substance ID |
7481999, 7980663, 10242949, 11111781, 11113955, 15195750, 26752102, 29310041, 47500606, 47721698, 48170518, 50104756, 57343891, 80006403, 85787816, 90340574, 103303610, 104011943, 104171236, 104375818, 124750211, 124881405, 124881406, 124881407, 129616753, 143286332, 162637546, 163583375, 178101133, 179235770, 218905729, 224847731, 230183040, 245703635, 249983985
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ChEBI ID |
CHEBI:92163
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Target and Pathway | Top | |||
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Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Modulator | [3] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4316). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001602) | |||
REF 3 | Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83-90. |
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