Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0ZY3E
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| Former ID |
DCL000136
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| Drug Name |
INO-1001
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| Synonyms |
Hypoxanthine arabinoside; LT00454797; 9-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
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| Drug Type |
Small molecular drug
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| Indication | Brain cancer [ICD-11: 2A00] | Phase 3 | [1], [2] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Inotek Pharma.
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)CO)O)O
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11341956, 11362139, 11364855, 11367417, 11369979, 11372318, 11375508, 11378147, 11485713, 11487541, 11489755, 11490975, 11493609, 11495724, 26613325, 26679890, 43328346, 48094522, 48169347, 80900411, 83548623, 92710479, 114937692, 121362243, 124637303, 126631840, 126658140, 135985675, 144076071, 152099856, 162173203, 179039799, 223399182, 226874784
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| SuperDrug ATC ID |
C03CA03
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| SuperDrug CAS ID |
cas=055837279
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase (PARP) | Target Info | Modulator | [1], [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12. | |||
| REF 2 | INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. Shock. 2004 May;21(5):426-32. | |||
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