Drug Information
Drug General Information | Top | |||
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Drug ID |
D0ZY6C
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Drug Name |
Diaryl piperazine derivative 1
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Synonyms |
PMID26161824-Compound-127
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Drug Type |
Small molecular drug
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Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
Company |
INTERVET INTERNATIONAL B.V. DEMONG, Duane, Eugene MILLER, Michael, W. GILBERT, Eric, J. SCOTT, Jack, D. STAMFORD, Andrew GREENLEE, William, J. CELLY, Chander, Shekher
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Structure |
Download2D MOL |
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Formula |
C24H22Cl2N2O2
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Canonical SMILES |
COC1=CC=CC=C1C(=O)N2CCN(C(C2)C3=CC=CC=C3)C4=C(C=C(C=C4)Cl)Cl
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InChI |
1S/C24H22Cl2N2O2/c1-30-23-10-6-5-9-19(23)24(29)27-13-14-28(21-12-11-18(25)15-20(21)26)22(16-27)17-7-3-2-4-8-17/h2-12,15,22H,13-14,16H2,1H3
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InChIKey |
HXMSNSZTEVRLDE-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
KEGG Pathway | Rap1 signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | ||||
Panther Pathway | Endogenous cannabinoid signaling | |||
Pathway Interaction Database | N-cadherin signaling events | |||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Small Ligand GPCRs | ||||
BDNF signaling pathway | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. |
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