Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DC23ER
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| Drug Name |
AZD9574
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| Synonyms |
AZD-9574; AZD9574; 2756333-39-6; 9UG32UQW48; UNII-9UG32UQW48; 2-Pyridinecarboxamide, 6-fluoro-5-(4-((5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl)-1-piperazinyl)-N-methyl-; 6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide; 6-fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide; CHEMBL5095223; SCHEMBL24156588; GTPL11946; GLXC-25685; EX-A6177; NSC840950; AKOS040759967; AT34947; NSC-840950; example 20 [WO2021260092A1]; MS-27579; HY-145804; CS-0433406; 6-FLUORO-5-(4-((5-FLUORO-2-METHYL-3-OXO-3,4-DIHYDROQUINOXALIN-6-YL)METHYL)PIPERAZIN-1-YL)-N-METHYLPICOLINAMIDE
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| Drug Type |
Small molecule
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| Indication | Aggressive cancer [ICD-11: 2A00-2F9Z; ICD-10: R45.6; ICD-9: 140-229] | Phase 2 | [1] | |
| Company |
AstraZeneca
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| Structure |
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Download2D MOL |
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| Formula |
C21H22F2N6O2
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| Canonical SMILES |
CC1=NC2=C(C(=C(C=C2)CN3CCN(CC3)C4=C(N=C(C=C4)C(=O)NC)F)F)NC1=O
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| InChI |
InChI=1S/C21H22F2N6O2/c1-12-20(30)27-18-14(25-12)4-3-13(17(18)22)11-28-7-9-29(10-8-28)16-6-5-15(21(31)24-2)26-19(16)23/h3-6H,7-11H2,1-2H3,(H,24,31)(H,27,30)
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| InChIKey |
WXRCLFFPZXJCLS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase (PARP) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05417594) A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies (CERTIS1). U.S.National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of AstraZeneca | |||
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