Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DCD1M8
|
|||
| Drug Name |
ABBV-621
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Haematological malignancy [ICD-11: 2B33.Y] | Phase 1 | [1] | |
| Hematologic tumour [ICD-11: 2B33.Y] | Phase 1 | [2] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | ||
| Company |
AbbVie
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TNF related apoptosis inducing ligand (TNFSF10) | Target Info | Agonist | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| FoxO signaling pathway | ||||
| Apoptosis | ||||
| Natural killer cell mediated cytotoxicity | ||||
| Measles | ||||
| Influenza A | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Pathway Interaction Database | TRAIL signaling pathway | |||
| Caspase Cascade in Apoptosis | ||||
| Reactome | Ligand-dependent caspase activation | |||
| Regulation by c-FLIP | ||||
| RIPK1-mediated regulated necrosis | ||||
| CASP8 activity is inhibited | ||||
| Dimerization of procaspase-8 | ||||
| TRAIL signaling | ||||
| WikiPathways | Apoptosis | |||
| Extrinsic Pathway for Apoptosis | ||||
| Apoptosis Modulation and Signaling | ||||
| TP53 Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT03082209) A Study of the Safety and Tolerability of ABBV-621 in Participants With Previously-Treated Solid Tumors and Hematologic Malignancies. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of AbbVie. | |||
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