Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DN9DB6
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| Drug Name |
SPH3127
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| Synonyms |
SPH3127; SPH-3127; 1399849-02-5; C2M78A9V6Z; CHEMBL4110551; SCHEMBL16471589; GTPL12196; BDBM212579; GLXC-26423; compound 18 [PMID: 35939295]; HY-151111; CS-0567609; US9278944, 270; Carbamic acid, N-(3-(3-((1R)-1-(cyclopropyl((2R)-2-morpholinylcarbonyl)amino)ethyl)-6-methyl-1H-pyrazolo(3,4-b)pyridin-1-yl)propyl)-, methyl ester; Methyl (3-(3-((R)-1-((R)-N-cyclopropylmorpholine-2-carboxamido)ethyl)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate
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| Drug Type |
Small molecule
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| Indication | Ulcerative colitis [ICD-11: DD71; ICD-9: 556] | Phase 2 | [1] | |
| Company |
Shanghai Pharma Biotherapeutics San Diego, CA
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| Structure |
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Download2D MOL |
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| Formula |
C22H32N6O4
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| Canonical SMILES |
CC1=NC2=C(C=C1)C(=NN2CCCNC(=O)OC)C(C)N(C3CC3)C(=O)C4CNCCO4
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| InChI |
InChI=1S/C22H32N6O4/c1-14-5-8-17-19(26-27(20(17)25-14)11-4-9-24-22(30)31-3)15(2)28(16-6-7-16)21(29)18-13-23-10-12-32-18/h5,8,15-16,18,23H,4,6-7,9-13H2,1-3H3,(H,24,30)/t15-,18-/m1/s1
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| InChIKey |
GRTDDIZIUSADLD-CRAIPNDOSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensinogenase renin (REN) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Renin-angiotensin system | |||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05770609) A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel, Dose-finding Phase II Clinical Study to Evaluate the Efficacy and Safety of SPH3127 Tablets in the Treatment of Mild to Moderate Ulcerative Colitis. U.S.National Institutes of Health. | |||
| REF 2 | Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor. J Med Chem. 2022 Aug 25;65(16):10882-10897. | |||
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