Drug Information
Drug General Information | Top | |||
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Drug ID |
DPIE08
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Drug Name |
ASP8731
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Synonyms |
ML-0207
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Drug Type |
Small molecule
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Indication | Sickle-cell disorder [ICD-11: 3A51; ICD-10: D57, D57.8; ICD-9: 282.5, 282.6] | Phase 1 | [1] | |
Company |
Astelllas
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Target and Pathway | Top | |||
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Target(s) | Transcription regulator protein BACH1 (Bach1) | Target Info | Inhibitor | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT05167526) A Phase 1 Combined Single and Multiple Ascending Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP8731 in Healthy Adult Participants, Including an Assessment of a Food Effect. U.S.National Institutes of Health. | |||
REF 2 | The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease. Front Med (Lausanne). 2023 Apr 18;10:1101501. |
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