Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DRT90B
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| Drug Name |
NSC632839
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| Synonyms |
157654-67-6; NSC 632839 hydrochloride; NSC-632839; Nsc 632839; NSC-632839 hydrochloride; 3,5-BIS[(4-METHYLPHENYL)METHYLENE]-4-PIPERIDONE HYDROCHLORIDE; 157654-67-6 (HCl); MLS002701647; C21H21NO.ClH; (3E,5E)-3,5-bis[(4-methylphenyl)methylidene]piperidin-4-one;hydrochloride; CHEMBL1990474; DTXSID10417701; AMY19345; BCP28077; EX-A4187; 2599AH; s4922; AKOS024457219; CS-6014; BS-15510; HY-100708; NSC 632839, >=98% (HPLC); J-009433; 3,5-bis((E)-4-methylbenzylidene)piperidin-4-one hydrochloride; 4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride; 4-Piperidinone,5-bis[(4-methylphenyl)methylene]-, hydrochloride; 4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Preclinical | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C21H22ClNO
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| Canonical SMILES |
CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl
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| InChI |
1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;
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| InChIKey |
ZOKZLTXPTLIWOJ-BYCVLTJGSA-N
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| CAS Number |
CAS 157654-67-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ubiquitin thioesterase L1 (UCHL1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Parkinson disease | |||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| WikiPathways | Parkinsons Disease Pathway | |||
| Proteasome Degradation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging therapies targeting the ubiquitin proteasome system in cancer. J Clin Invest. 2014 Jan;124(1):6-12. | |||
| REF 2 | Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity. Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733. | |||
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