| Target's General Information |
| Target ID |
T06093 |
| Target Name |
Rho-associated protein kinase 2 (ROCK2) |
| Synonyms |
p164 ROCK-2; Rho-associated, coiled-coil-containing protein kinase II; Rho-associated, coiled-coil-containing protein kinase 2; Rho kinase 2; ROCK-II; KIAA0619 |
| Target Type |
Successful |
| Gene Name |
ROCK2 |
| Biochemical Class |
Kinase |
| UniProt ID |
ROCK2_HUMAN |
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People |
| Disease |
Chronic obstructive pulmonary disease |
| Tissue |
Lung tissue |
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 6.89E-03
Z-score: 0.03
P-value: 8.76E-01
|
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
| Disease |
Chronic obstructive pulmonary disease |
| Tissue |
Small airway epithelium |
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.09
Z-score: -0.39
P-value: 1.39E-02
|
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
| Disease |
Rheumatoid arthritis |
| Tissue |
Synovial tissue |
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.12
Z-score: 0.71
P-value: 1.55E-01
|
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
| Target's Expression Profile across Various Tissues of Healthy Individual |
|
| References |
| REF 1 |
Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
|
| REF 2 |
NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.
|
