Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T15344 | ||||
| Target Name | Activation-inducible TNFR family receptor (TNFRSF18) | ||||
| Synonyms | UNQ319/PRO364; Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; GITR; CD357; AITR | ||||
| Target Type | Clinical trial | ||||
| Gene Name | TNFRSF18 | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | TNR18_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Melanoma | ||||
| Example drug | TRX-518 | Phase 1 | [1], [2] | ||
| Tissue | Skin | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.54 Z-score: -0.7 P-value: 2.39E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01239134) Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid Tumors. U.S. National Institutes of Health. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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