Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T29960 | ||||
| Target Name | Wilms tumor protein (WT1) | ||||
| Synonyms | Wilms' tumour 1 protein; WT33; WT1 protein | ||||
| Target Type | Clinical trial | ||||
| Gene Name | WT1 | ||||
| Biochemical Class | EGR C2H2-type zinc-finger | ||||
| UniProt ID | WT1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | Combined PR1/WT1 vaccine | Phase 2 | [1], [2], [3] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 1.54 Z-score: 7.84 P-value: 5.12E-79 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies. Front Immunol. 2015 Feb 4;6:36. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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