Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T46084 | ||||
| Target Name | TNF related apoptosis inducing ligand (TNFSF10) | ||||
| Synonyms | Tumor necrosis factor ligand superfamily member 10; TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253; Apo-2L; Apo-2 ligand; APO2L | ||||
| Target Type | Clinical trial | ||||
| Gene Name | TNFSF10 | ||||
| Biochemical Class | Cytokine: tumor necrosis factor | ||||
| UniProt ID | TNF10_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Rectal cancer | ||||
| Example drug | Dulanermin | Terminated | [1], [2], [3] | ||
| Tissue | Rectal colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -1.09 Z-score: -3.9 P-value: 1.16E-05 |
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| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: -1.69 Z-score: -3.77 P-value: 1.57E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Brain cancer | ||||
| Example drug | DA-3607 | Phase 1 | [2], [3], [4] | ||
| Tissue | Nervous tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.16 Z-score: -0.18 P-value: 4.40E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Prostate cancer | ||||
| Example drug | Ad5-TRAIL | Phase 1 | [2], [3], [5] | ||
| Tissue | Prostate | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.18 Z-score: 0.37 P-value: 9.66E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of Genentech (2011). | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657) | ||||
| REF 5 | Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396. | ||||
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