Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T49639 | ||||
| Target Name | Heat shock protein 70 (HSP70) | ||||
| Synonyms | Heat shock 70 kDa protein; HSP72; HSP70 | ||||
| Target Type | Clinical trial | ||||
| Gene Name | HSPA1A; HSPA1B | ||||
| Biochemical Class | Heat shock protein | ||||
| UniProt ID | HS71A_HUMAN||HS71B_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | AG-858 | Phase 2 | [1], [2], [3] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.32 Z-score: 1.2 P-value: 1.03E-20 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Gastric cancer | ||||
| Example drug | Minnelide | Phase 1 | [2], [3], [4] | ||
| Tissue | Gastric tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -4.07E-03 Z-score: -0.01 P-value: 2.62E-01 |
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| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: 0.41 Z-score: 1.2 P-value: 3.38E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00058747) AG-858 in Patients Who Are Cytogenetically Positive After Treatment With Gleevec . U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | ClinicalTrials.gov (NCT01927965) Study of Minnelide in Patients With Advanced GI Tumors. U.S. National Institutes of Health. | ||||
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