Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T50688 | ||||
| Target Name | Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) | ||||
| Synonyms | Platelet membrane glycoprotein IIb; Platelet membrane glycoprotein IIIa; GP | ||||
| Target Type | Successful | ||||
| Gene Name | ITGA2B; ITGB3 | ||||
| UniProt ID | ITA2B_HUMAN||ITB3_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Arteriosclerosis | ||||
| Example drug | Gantofiban | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.1 Z-score: 0.39 P-value: 8.97E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Coronary artery disease | ||||
| Example drug | DMP-444 | Phase 3 | [2], [3], [4] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.11 Z-score: -0.45 P-value: 7.83E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010688) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Evaluation of 99mTc-labeled cyclic RGD peptide with a PEG4 linker for thrombosis imaging: comparison with DMP444. Bioconjug Chem. 2011 Aug 17;22(8):1715-22. | ||||
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