Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T51487 | ||||
| Target Name | GABA(A) receptor alpha-1 (GABRA1) | ||||
| Synonyms | Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1 | ||||
| Target Type | Successful | ||||
| Gene Name | GABRA1 | ||||
| Biochemical Class | Ligand-gated ion channel | ||||
| UniProt ID | GBRA1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Depression | ||||
| Example drug | Barbituric acid | Approved | [1], [2], [3] | ||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.12 Z-score: -0.18 P-value: 9.57E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Epilepsy | ||||
| Example drug | Nitrazepam | Approved | [2], [3], [4], [5] | ||
| Tissue | Peritumoral cortex tissue | ||||
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Drug information of Nitrazepam, 2008. eduDrugs. | ||||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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