Target's General Information
Target ID T51487
Target Name GABA(A) receptor alpha-1 (GABRA1)
Synonyms Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1
Target Type Successful
Gene Name GABRA1
Biochemical Class Ligand-gated ion channel
UniProt ID GBRA1_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Depression
Example drug Barbituric acid Approved [1], [2], [3]
Tissue Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.12
Z-score: -0.18
P-value: 9.57E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Epilepsy
Example drug Nitrazepam Approved [2], [3], [4], [5]
Tissue Peritumoral cortex tissue
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.
REF 4 Drug information of Nitrazepam, 2008. eduDrugs.
REF 5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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