Target's General Information
Target ID T53024
Target Name Somatostatin receptor type 2 (SSTR2)
Synonyms Sst(2); Somatostatin receptor 2; SS2R; SS2-R; SS-2-R; SRIF-1
Target Type Successful
Gene Name SSTR2
Biochemical Class GPCR rhodopsin
UniProt ID SSR2_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Alzheimer's disease
Example drug FR-121196 Terminated [1], [2], [3]
Tissue Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.38
Z-score: -0.65
P-value: 9.79E-07
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Lung cancer
Example drug Re-188-P-2045 Phase 1/2 [2], [3], [4]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.05
Z-score: 0.21
P-value: 2.41E-05
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 0.03
Z-score: 0.08
P-value: 3.85E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Melanoma
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.22
Z-score: 0.28
P-value: 4.36E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.
REF 4 The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts. J Nucl Med. 2014 Dec;55(12):2020-5.

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