Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T62276 | ||||
| Target Name | Glutamate receptor ionotropic NMDA 1 (NMDAR1) | ||||
| Synonyms | NmethylDaspartate receptor subunit NR1; NMDR1; NMD-R1; N-methyl-D-aspartate receptor subunit NR1; Glutamate receptor ionotropic, NMDA 1; Glutamate [NMDA] receptor subunit zeta1; Glutamate [NMDA] receptor subunit zeta-1; GluN1 | ||||
| Target Type | Successful | ||||
| Gene Name | GRIN1 | ||||
| Biochemical Class | Glutamate-gated ion channel | ||||
| UniProt ID | NMDZ1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Multiple sclerosis | ||||
| Example drug | ELIPRODIL | Phase 2 | [1], [2], [3] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: -0.17 Z-score: -1.25 P-value: 2.00E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Parkinson's disease | ||||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.5 Z-score: -1.8 P-value: 1.12E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00001929) Treatment of Parkinson's Disease With Eliprodil. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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