Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T63414 | ||||
| Target Name | P2X purinoceptor 7 (P2RX7) | ||||
| Synonyms | Purinergic receptor 7; P2Z receptor; P2X7; Adenosine P2X7 receptor; ATP receptor | ||||
| Target Type | Clinical trial | ||||
| Gene Name | P2RX7 | ||||
| Biochemical Class | ATP-gated P2X receptor cation channel | ||||
| UniProt ID | P2RX7_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Rheumatoid arthritis | ||||
| Example drug | EVT 401 | Phase 1 | [1], [2], [3] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 1.08 Z-score: 1.25 P-value: 1.71E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Alzheimer's disease | ||||
| Example drug | JNJ-479655 | Clinical trial | [2], [3], [4] | ||
| Tissue | Entorhinal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.37 Z-score: 0.49 P-value: 1.11E-06 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.1 Z-score: -0.22 P-value: 3.17E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Tissue | Small airway epithelium | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.16 Z-score: 0.37 P-value: 5.97E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of Evotec. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci. 2013 Mar;53:52-62. | ||||
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