Target's General Information
Target ID T65883
Target Name Claudin-18 (CLDN18)
Synonyms UNQ778/PRO1572; Claudin18
Target Type Clinical trial
Gene Name CLDN18
UniProt ID CLD18_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Esophagal cancer
Example drug Claudiximab Phase 2 [1], [2], [3]
Tissue Esophagus
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 0.13
Z-score: 1.09
P-value: 1.75E-05
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 ClinicalTrials.gov (NCT01197885) Efficacy and Safety Study of Multiple Doses of IMAB362 in Patients With Advanced Gastroesophageal Cancer. U.S. National Institutes of Health.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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