Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T68782 | ||||
| Target Name | Prostaglandin D2 receptor (PTGDR) | ||||
| Synonyms | Prostanoid DP receptor; PGD2 receptor; PGD receptor | ||||
| Target Type | Clinical trial | ||||
| Gene Name | PTGDR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | PD2R_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Asthma | ||||
| Example drug | QAW-039 | Phase 3 | [1], [2], [3] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.14 Z-score: -0.23 P-value: 7.32E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Atopic dermatitis | ||||
| Example drug | TS-022 | Phase 2 | [2], [3], [4] | ||
| Tissue | Skin | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.05 Z-score: -0.2 P-value: 7.32E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02563067) Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | ClinicalTrials.gov (NCT00914186) Study of TS-022 in Adult Patients With Atopic Dermatitis With Pruritus (POC). U.S. National Institutes of Health. | ||||
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