Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T76198 | ||||
| Target Name | Thromboxane A2 receptor (TBXA2R) | ||||
| Synonyms | TXA2-R; TXA2 receptor; Prostanoid TP receptor | ||||
| Target Type | Successful | ||||
| Gene Name | TBXA2R | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | TA2R_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Asthma | ||||
| Example drug | KP-496 | Phase 2 | [1], [2], [3] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.11 Z-score: -0.31 P-value: 2.78E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergol Int. 2006 Dec;55(4):403-10. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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