Target's General Information
Target ID T79160
Target Name Glial cell line-derived neurotrophic factor (GDNF)
Synonyms hGDNF; Glial cell linederived neurotrophic factor; Astrocytederived trophic factor; Astrocyte-derived trophic factor; ATF
Target Type Clinical trial
Gene Name GDNF
Biochemical Class Growth factor
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Lateral sclerosis
Example drug Liatermin Phase 1/2 [1], [2], [3]
Tissue Cervical spinal cord
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.08
Z-score: 0.31
P-value: 2.29E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
REF 1 (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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