Target expression details
Target's General Information | |||||
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Target ID | T85158 | ||||
Target Name | Lymphotoxin-alpha (LTA) | ||||
Synonyms | Tumor necrosis factor ligand superfamily member 1; TNFSF1; TNFB; TNF-beta; LT-alpha | ||||
Target Type | Clinical trial | ||||
Gene Name | LTA | ||||
Biochemical Class | Cytokine: tumor necrosis factor | ||||
UniProt ID | TNFB_HUMAN | ||||
Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
Disease | Rheumatoid arthritis | ||||
Example drug | Anti-LT alpha | Phase 2 | [1], [2], [3] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.19 Z-score: -0.92 P-value: 9.54E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target's Expression Profile across Various Tissues of Healthy Individual | |||||
References | |||||
REF 1 | Clinical pipeline report, company report or official report of Genentech (2011). | ||||
REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. |
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