Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T93344 | ||||
| Target Name | Squalene monooxygenase (SQLE) | ||||
| Synonyms | Squalene epoxidase; SQLE; SE; Oxidosqaulene cyclase | ||||
| Target Type | Successful | ||||
| Gene Name | SQLE | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | ERG1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Coronary artery disease | ||||
| Example drug | SDZ-87-469 | Terminated | [1], [2], [3] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.19 Z-score: 1.16 P-value: 5.26E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Familial hypercholesterolemia | ||||
| Example drug | FR-194738 | Terminated | [2], [3], [4] | ||
| Tissue | Whole blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.45 Z-score: 2.51 P-value: 7.14E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Atopic dermatitis | ||||
| Tissue | Skin | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.65 Z-score: -2.3 P-value: 2.61E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Chemotherapy of fungal diseases. 1990. Page(525-550). | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009590) | ||||
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