Target's General Information
Target ID T97613
Target Name Melatonin receptor type 1A (MTNR1A)
Synonyms Mel1a receptor; Mel1AR; Mel-1A-R
Target Type Successful
Gene Name MTNR1A
Biochemical Class GPCR rhodopsin
UniProt ID MTR1A_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Depression
Example drug Agomelatine Withdrawn from market [1], [2], [3], [4]
Tissue Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.08
Z-score: -0.54
P-value: 5.71E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 198).
REF 2 Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
REF 3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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