miRNA General Information
miRNA Mature ID hsa-miR-125b-1-3p
miRNA Stemloop AC MI0000446
miRNA Stemloop ID hsa-mir-125b-1
Sequence acggguuaggcucuugggagcu
TTD Target(s) Regulated by This miRNA Sphingosine-1-phosphate receptor 1 (S1PR1) Successful Target Target Info [1]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [2]
Sphingosine-1-phosphate lyase 1 (SGPL1) Clinical trial Target Target Info [3]
ERK activator kinase 7 (MAP2K7) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA Bcl-2-interacting killer Regulated Protein [5]
Integrin alpha-9 Regulated Protein [6]
Mitochondrial fission process protein 1 Regulated Protein [5]
Osteocalcin Regulated Protein [7]
Secreted frizzled-related protein 3 Regulated Protein [7]
Tumor-associated calcium signal transducer 2 Regulated Protein [8]
REF 1 miR-125b-1-3p inhibits trophoblast cell invasion by targeting sphingosine-1-phosphate receptor 1 in preeclampsia. Biochem Biophys Res Commun. 2014 Oct 10;453(1):57-63.
REF 2 Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress. RNA Biol. 2016 Nov;13(11):1152-1165.
REF 3 miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1. PLoS One. 2016 Dec 9;11(12):e0166940.
REF 4 miR-125b inhibited epithelial-mesenchymal transition of triple-negative breast cancer by targeting MAP2K7. Onco Targets Ther. 2016 May 4;9:2639-48.
REF 5 miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics.Blood. 2016 Dec 29;128(26):3125-3136.
REF 6 MicroRNA-125b suppresses the epithelial-mesenchymal transition and cell invasion by targeting ITGA9 in melanoma.Tumour Biol. 2016 May;37(5):5941-9.
REF 7 Global miRNA expression and correlation with mRNA levels in primary human bone cells.RNA. 2015 Aug;21(8):1433-43.
REF 8 Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway.Oncogene. 2014 Feb 6;33(6):702-12.

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