miRNA General Information
miRNA Mature ID hsa-miR-216b-5p
miRNA Stemloop AC MI0005569
miRNA Stemloop ID hsa-mir-216b
Sequence aaaucucugcaggcaaauguga
TTD Target(s) Regulated by This miRNA Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Target Info [1]
Casein kinase II alpha (CSNK2A1) Clinical trial Target Target Info [2]
Histone deacetylase 8 (HDAC8) Clinical trial Target Target Info [3]
Transcription factor AP-1 (JUN) Discontinued Target Target Info [4]
PDZ binding kinase (PBK) Literature-reported Target Target Info [5]
Forkhead box protein M1 (FOXM1) Literature-reported Target Target Info [6]
Beclin-1 (BECN1) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA UDP-glucuronosyltransferase 2B7 Regulated Protein [8]
REF 1 MiR-216b increases cisplatin sensitivity in ovarian cancer cells by targeting PARP1. Cancer Gene Ther. 2017 May;24(5):208-214.
REF 2 MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting subunit of protein kinase CKII in human colorectal cancer cells. Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):173-9.
REF 3 MicroRNA-216b is Down-Regulated in Human Gastric Adenocarcinoma and Inhibits Proliferation and Cell Cycle Progression by Targeting Oncogene HDAC8. Target Oncol. 2016 Apr;11(2):197-207.
REF 4 miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016 May 13;7:11422.
REF 5 miR-216b promotes cell growth and enhances chemosensitivity of colorectal cancer by suppressing PDZ-binding kinase. Biochem Biophys Res Commun. 2017 Jun 24;488(2):247-252.
REF 6 microRNA-216b inhibits cell proliferation and migration in human melanoma by targeting FOXM1 in vitro and in vivo. Cell Biol Int. 2017 Dec;41(12):1272-1282.
REF 7 MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure. Exp Eye Res. 2014 Jun;123:43-55.
REF 8 Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.J Pharmacol Exp Ther. 2016 Oct;359(1):182-93.

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