miRNA General Information
miRNA Mature ID hsa-miR-485-5p
miRNA Stemloop AC MI0002469
miRNA Stemloop ID hsa-mir-485
Sequence agaggcuggccgugaugaauuc
TTD Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [1]
Frizzled-7 receptor (FZD7) Clinical trial Target Target Info [2]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [3]
Stanniocalcin-2 (STC2) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA Apolipoprotein A-V Regulated Protein [5]
Flotillin-1 Regulated Protein [6]
Hypoxia-inducible factor 3-alpha Regulated Protein [7]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Regulated Protein [8]
REF 1 Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010 Jun 11;38(5):689-99.
REF 2 MicroRNA-485-5p represses melanoma cell invasion and proliferation by suppressing Frizzled7. Biomed Pharmacother. 2017 Jun;90:303-310.
REF 3 miR 85 p inhibits bladder cancer metastasis by targeting HMGA2. Int J Mol Med. 2015 Oct;36(4):1136-42.
REF 4 MicroRNA-485-5p suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting stanniocalcin 2. Int J Clin Exp Pathol. 2015 Oct 1;8(10):12292-9.
REF 5 An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.Am J Hum Genet. 2014 Jan 2;94(1):129-34.
REF 6 miR-485-5p acts as a negative regulator in gastric cancer progression by targeting flotillin-1. Am J Transl Res. 2015 Nov 15;7(11):2212-22.
REF 7 MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3.BMC Cancer. 2014 Jun 13;14:429.
REF 8 MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1 expression.Cell Death Dis. 2016 Mar 24;7:e2159.

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