miRNA Details
| miRNA General Information | |||||
|---|---|---|---|---|---|
| miRNA Mature ID | hsa-miR-493-3p | ||||
| miRNA Stemloop AC | MI0003132 | ||||
| miRNA Stemloop ID | hsa-mir-493 | ||||
| Sequence | ugaaggucuacugugugccagg | ||||
| TTD Target(s) Regulated by This miRNA | Dickkopf-related protein 1 (DKK1) | Clinical trial Target | Target Info | [1] | |
| ERK activator kinase 7 (MAP2K7) | Literature-reported Target | Target Info | [2] | ||
| Protein(s) Regulated by This miRNA | Frizzled-4 | Regulated Protein | [3] | ||
| Max-interacting protein 1 | Regulated Protein | [4] | |||
| Rho-related GTP-binding protein RhoC | Regulated Protein | [3] | |||
| References | |||||
| REF 1 | miR-493 mediated DKK1 down-regulation confers proliferation, invasion and chemo-resistance in gastric cancer cells. Oncotarget. 2016 Feb 9;7(6):7044-54. | ||||
| REF 2 | MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Cancer Sci. 2014 Apr;105(4):425-30. | ||||
| REF 3 | Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4.Mol Cancer Ther. 2012 Jan;11(1):244-53. | ||||
| REF 4 | Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel.Oncotarget. 2016 Mar 15;7(11):12267-85. | ||||
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