miRNA General Information
miRNA Mature ID hsa-miR-638
miRNA Stemloop AC MI0003653
miRNA Stemloop ID hsa-mir-638
Sequence agggaucgcgggcggguggcggccu
TTD Target(s) Regulated by This miRNA Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Target Info [1]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [2]
Phospholipase D1 (PLD1) Patented-recorded Target Target Info [3]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [2]
Transcription factor SOX-2 (SOX2) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA Dapper homolog 3 Regulated Protein [5]
Protein OSCP1 Regulated Protein [6]
START domain-containing protein 10 Regulated Protein [7]
Transcription factor Sp2 Regulated Protein [8]
Tumor protein p53-inducible nuclear protein 2 Regulated Protein [9]
REF 1 miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2. J Biol Chem. 2015 Jan 16;290(3):1818-28.
REF 2 Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep. 2014 Aug 7;8(3):714-22.
REF 3 MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma. Protein Cell. 2015 Sep;6(9):680-688.
REF 4 Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells. Mol Cancer. 2014 May 23;13:118.
REF 5 MiRNA-638 promotes autophagy and malignant phenotypes of cancer cells via directly suppressing DACT3.Cancer Lett. 2017 Apr 1;390:126-136.
REF 6 MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1.Cardiovasc Res. 2013 Jul 1;99(1):185-93.
REF 7 Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells.Biochem Biophys Res Commun. 2017 May 27;487(2):255-261.
REF 8 miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2.Dig Dis Sci. 2014 Aug;59(8):1743-53.
REF 9 miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy.Oncotarget. 2015 Feb 20;6(5):2966-80.

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